AI-Enabled CT Cardiac Chamber Volumetry Predicts Atrial Fibrillation and Stroke Comparable to MRI

Morteza Naghavi MD, Anthony P. Reeves PhD, Kyle C. Atlas MS, Chenyu Zhang MS, Dong Li PhD, Thomas Atlas MD, Claudia I. Henschke MD, Nathan D. Wong PhD, Sion K. Roy MD, Matthew J. Budoff MD, David F. Yankelevitz MD

a. HeartLung.AI, Houston, Texas, USA

b. Department of Electrical and Computer Engineering, Cornell University, New York, USA

c. Division of Cardiology, The Lundquist Institute, Torrance, California, USA

d. Department of Radiology, Tustin Teleradiology, Tustin, California, USA

e. Department of Radiology, Mount Sinai Hospital, New York, New York, USA

f. Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, California, USA

Abstract

Background:

AI-CAC provides more actionable information than the Agatston coronary artery calcium (CAC) score. We have recently shown in the MESA (Multi-Ethnic Study of Atherosclerosis) that AI-CAC automated left atrial (LA) volumetry enabled prediction of atrial fibrillation (AF) as early as 1 year.

Objectives:

In this study, the authors evaluated the performance of AI-CAC LA volumetry versus LA measured by human experts using cardiac magnetic resonance imaging (CMRI) for predicting incident AF and stroke and compared them with Cohorts for Heart and Aging Research in Genomic Epidemiology model for atrial fibrillation (CHARGE-AF) risk score, Agatston score, and N-terminal pro b-type natriuretic peptide (NT-proBNP).

Methods:

We used 15-year outcomes data from 3,552 asymptomatic individuals (52.2% women, age 61.7 ± 10.2 years) who underwent both CAC scans and CMRI in the MESA baseline examination. CMRI LA volume was previously measured by human experts. Data on NT-proBNP, CHARGE-AF risk score, and the Agatston score were obtained from MESA. Discrimination was assessed using the time-dependent area under the curve.

Results:

Over 15 years follow-up, 562 cases of AF and 140 cases of stroke accrued. The area under the curve for AI-CAC versus CMRI volumetry for AF (0.802 vs 0.798) and stroke (0.762 vs 0.751) were not significantly different. AI-CAC LA significantly improved the continuous net reclassification index for prediction of 5-year AF when added to CHARGE-AF risk score (0.23), NT-proBNP (0.37, 0.37), and Agatston score (0.44) (P for all <0.0001).

Conclusions:

AI-CAC automated LA volumetry and CMRI LA volume measured by human experts similarly predicted incident AF and stroke over 15 years. Further studies to investigate the clinical utility of AI-CAC for AF and stroke prediction are warranted.