Agatston-2.0: A New Generation of AI-Based Coronary Calcium Analysis

Agatston-2.0 is a next-generation artificial intelligence framework developed to enhance cardiovascular risk assessment in individuals with Agatston coronary artery calcium (CAC) scores below 100—a population that represents nearly 75% of individuals undergoing CAC scanning and accounts for a substantial proportion of future coronary heart disease events.

Rather than relying solely on conventional calcium scoring, Agatston-2.0 introduces advanced AI-derived biomarkers that analyze the distribution, density, and spatial characteristics of coronary calcification. By combining these novel imaging biomarkers with additional AI-CVD cardiometabolic measurements—including cardiac chamber volumes, visceral fat, and epicardial fat—the platform provides a more comprehensive evaluation of cardiovascular risk.

The presented data demonstrate that Agatston-2.0 can identify high-risk individuals who would otherwise be classified as low risk by traditional CAC scoring alone. The AI-based approach also shows strong correlation with coronary plaque burden on coronary CT angiography (CCTA), enabling more accurate risk stratification and supporting earlier preventive intervention.

This presentation highlights the scientific foundation, AI methodology, validation studies, and clinical implications of Agatston-2.0, illustrating how artificial intelligence can redefine the role of coronary calcium scoring in modern preventive cardiology.

Download the complete presentation below to explore the full workflow, validation results, and clinical evidence behind Agatston-2.0.

Agatston 2.0 SCCT July 9th 2026 - v3.pptx

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